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Contraindicated (1)pentobarbital will lower the extent or influence of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with strong CYP3A4 inducers just isn't advisablepentobarbital will lessen the extent or impact of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/S